US 20120251502 A1
ABSTRACT
Compositions and methods including and related to the Ebola Bundibugyo virus (EboBun) are provided. Compositions are provided that are operable as immunogens to elicit and immune response or protection from EboBun challenge in a subject such as a primate. Inventive methods are directed to detection and treatment of EboBun infection.
DESCRIPTION
This application claims priority benefit of U.S. Provisional Application 61/108,175 filed 24 Oct. 2008; the contents of which are hereby incorporated by reference.
The invention provides the isolated human Ebola (hEbola) viruses denoted as Bundibugyo (EboBun) deposited with the Centers for Disease Control and Prevention (“CDC”; Atlanta, Ga., United States of America) on Nov. 26, 2007 and accorded an accession number 200706291. This deposit was not made to an International Depository Authority (IDA) as established under the Budapest Treaty on the International Recognition of the Deposit of Microorganisms for the Purposes of Patent Procedure, and is a non-Budapest treaty deposit. The deposited organism is not acceptable by American Type Culture Collection (ATCC), Manassas, Va., an International Depository Authority (IDA) as established under the Budapest Treaty on the International Recognition of the Deposit of Microorganisms for the Purposes of Patent Procedure. Samples of the stated Deposit Accession No. 200706291 will be made available to approved facilities for thirty years from the date of deposit, and for the lifetime of the patent issuing from, or claiming priority to this application.
The invention is related to compositions and methods directed to a novel species of human Ebola (hEbola) virus.
The family Filoviridae consists of two genera, Marburgvirus and Ebolavirus, which have likely evolved from a common ancestor1. The genus Ebolavirus includes four species: Zaire, Sudan, Reston and Côte d'Ivoire (Ivory Coast) ebolaviruses, which have, with the exception of Reston and Côte d'Ivoire ebolaviruses, been associated with large hemorrhagic fever (HF) outbreaks in Africa with high case fatality (53-90%)2
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| Publication number | US20120251502 A1 |
| Publication type | Application |
| Application number | US 13/125,890 |
| PCT number | PCT/US2009/062079 |
| Publication date | Oct 4, 2012 |
| Filing date | Oct 26, 2009 |
| Priority date | Oct 24, 2008 |
| Also published as | CA2741523A1, 4 More » |
| Inventors | Jonathan S. Towner, 4 More » |
| Original Assignee | The Government of the US as Represented by the Secretary of the Dept. of health |
| Export Citation | BiBTeX, EndNote, RefMan |
| Patent Citations (2), Non-Patent Citations (8), Classifications (39),Legal Events (1) | |
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